Klotho polymorphisms longevity
WebMay 22, 2024 · Klotho polymorphisms have been previously associated with longevity (defined, depending on the study, as people over the age of 66, 75 or 93 years) in … WebDec 14, 2024 · Previous genetic studies conducted on humans have implied the possible association of Klotho gene polymorphisms with longevity and CVDs. Nonetheless, they only succeeded in yielding a limited number of results. Thus, as the need was strongly felt, this study evaluated the Klotho gene polymorphism in Iranian subjects to reveal its possible ...
Klotho polymorphisms longevity
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WebJan 27, 2005 · In the current study, we presented strong evidence confirming the role of a common variant of KLOTHO, the KL-VS allele, in human longevity. Cross-sectional and … WebAug 27, 2024 · Klotho has been recognized as a gene involved in the aging process in mammals for over 30 years, where it regulates phosphate homeostasis and the activity of …
WebThe main spot of Klotho activity is kidney and in the physiological state presumably the most important one. 6 This idea is warranted by the study made on mice with a kidney-specific ablation of Klotho which demonstrated the phenotype of global Klotho knockout mice. 21 The serum soluble Klotho was declined about 80% in those kidney-specific ... WebJun 5, 2014 · This study investigated polymorphisms of a metabolism-related gene, Klotho, and an inflammatory gene, IL6, for association with the aging process in a healthy Han …
WebMar 1, 2024 · Klotho gene polymorphisms have been implicated in healthy aging, but inconsistences in findings from previous case-control studies have raised concerns regarding the associations between KLOTHO gene polymorphisms and susceptibility to aging-related diseases and longevity. Hence, this meta-analysis was performed. We … WebApr 15, 2024 · Klotho is a transmembrane protein that is involved in promoting longevity in mammals. The KLOTHO (KL) gene, which is found in chromosome 13q12, has major and minor alleles . The minor allele is a haplotype of two single nucleotide polymorphisms (SNPs), with the IDs rs9536314 and rs9527025, which remain in perfect linkage …
WebJan 15, 2002 · To determine whether the KLOTHO gene is involved in human aging, we used a population-based association study employing two newly characterized flanking microsatellite markers. Marker 1 is ≈11 kb 3′ of the last exon, and Marker 2 is ≈66 kb 5′ of the first exon. We present evidence that the KLOTHO locus is associated with human …
WebApr 16, 2024 · Its discovery in mice in 1997 was highly exciting because KLOTHO knockout mice had a short lifespan and showed a phenotype reminiscent of human aging. 1 In humans, a KLOTHO polymorphism called KL-VS is associated with extreme longevity. 2 Footnotes Go to Neurology.org/N for full disclosures. linux command yum not found did you meanWebThis study correlated the VDR gene polymorphisms (FokI, ApaI, BsmiI, and TaqI) with frailty, computed by frailty index (FI), in 202 persons (127 women and 75 men, aged from 60 to 116 years), aiming to capture the involvement of vitamin D in the sex-frailty paradox. ... Klotho is a bona fide longevity gene that, if inactivated, generates a ... linux compatible avec windows 10Webphisms (SNPs) associated with longevity were identified in genes encoding proteins that take part in this metabolic pathway. Closely related to this pathway is the Klotho gene. linux comme windowsWebAlzheimer's disease (AD) is the most common type of senile dementia.The antiaging gene Klotho is reported to decline in the brain of patients and animals with AD. However, the role of Klotho in the progression of AD remains elusive. The present study explored the effects and underlying mechanism of Klotho in a mouse model of AD. linux committed_asBone Mineral Density was measured using dual-energy X-ray absorptiometry (DXA, Hologic Inc. Bedford, MA, USA) at the lumbar spine, femoral neck, and total hip. All BMD measurements were performed by the same experienced technologist, following the recommendations by the International Society for Clinical … See more This study was based on data from the São Paulo Ageing & Health (SPAH) Study, which surveyed 65-year-old and older individuals living in a community in the … See more Each subject was interviewed by a physician and responded to a standard questionnaire designed to gather information about lifestyle, health behaviours, and … See more Osteoporotic fracture was defined as a fracture occurring at sites characteristic of bone fragility (e.g., the rib, spine, forearm, humerus, and femur) on fifty-year … See more Appendicular skeletal muscle mass (ASM) was measured by DXA: ASM relative to height and total fat mass were assessed. Relative ASM was derived by … See more linux command who is in groupWebMar 1, 2024 · Klotho polymorphisms have been previously associated with longevity (defined, depending on the study, as people over the age of 66, 75 or 93 years) in … house for rent in bloomington ilWebOct 1, 2015 · Only one case of a human α-Klotho mutation has been described to date, but polymorphisms in the α-Klotho gene (KL-VS variant) are associated with normal human aging . Given the implications of these discoveries for human health, there has been much interest in molecules such as α-Klotho as potential longevity-modulating therapeutic … house for rent in bonaire