Webb3 juni 2024 · Atorvastatin, simvastatin, pitavastatin, and fluvastatin were classified as lipophilic statins, whereas rosuvastatin and pravastatin were hydrophilic statins. 24 … Webb5 aug. 2024 · The drugs come in two categories, based on their solubility: lipophilic statins, such as simvastatin and lovastatin, dissolve in fats; while hydrophilic statins, such as pravastatin and rosuvastatin, dissolve in water.
Pharmacy Clinical Pearl of the Day: Lipophilic Statins vs …
Webb18: A method of reducing risk of one or more of: myocardial infarction, stroke, cardiovascular death, unstable angina, coronary revascularization procedures and/or hospitalization Webblipophilic statins (atorvastatin, fluvastatin, lovastatin, simvastatin) undergo hepatic and enteric metabolism via the cytochrome P450 (CYP450) system (1,2,3,4) water soluble … how can i get windows 11
Statin Lipophilicity and the Risk of Incident Heart Failure
WebbIn this study, hydrophilic statins (OR = 0.78; 95% CI = 0.66–0.92) and lipophilic statins (OR = 0.91; 95% CI = 0.84–0.99) used for a short-term period (180–545 days) were … Webb17 juli 2015 · Pravastatin and rosuvastatin are relatively hydrophilic and not significantly metabolized by cytochrome P(450) enzymes. All statins are selective for effect in the liver, largely because of efficient first-pass uptake; passive diffusion through hepatocyte cell membranes is primarily responsible for hepatic uptake of lipophilic statins, while … Webb1 okt. 2024 · simvastatin (Zocor) fluvastatin (Lescol) pitavastatin (Livalo) lovastatin (Altoprev) and atorvastatin (Lipitor). Switching to a different type of statin, called a hydrophilic statin — either rosuvastatin (Crestor) or pravastatin (Pravachol) — might be an option to discuss with your doctor, says Dr. Manson. how can i get windows 10 back